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Formation of Salicylic Acid/4,4′‐Dipyridyl Cocrystals Based on the Ternary Phase Diagram
Author(s) -
Lee KyeongSill,
Kim KwangJoo,
Ulrich Joachim
Publication year - 2015
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201400738
Subject(s) - solubility , crystallization , phase diagram , dissolution , cocrystal , ternary operation , chemistry , stoichiometry , solvent , thermodynamics , salicylic acid , phase (matter) , materials science , chemical engineering , organic chemistry , molecule , hydrogen bond , physics , biochemistry , computer science , programming language , engineering
The solubility behavior of salicylic acid (SAA)/4,4′‐dipyridyl (4,4′‐dipy) cocrystals is investigated in an ethanol solvent. The phase solubility diagram (PSD) of SAA/4,4′‐dipy cocrystals is determined which are formed in a 2:1 stoichiometric ratio in ethanol. The objective is to improve the fundamentals of the formation mechanisms, solution behavior, and solid‐state properties of SAA/4,4′‐dipy cocrystals. The solubility behavior and solution chemistry of cocrystals are studied. It was found that the thermodynamic stability regions of the cocrystals and its components are defined by the phase solubility diagram. Besides the kinetic also the thermodynamic factor turned out to be important for the crystallization of cocrystals.