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Bromination of Aromatic Compounds using Bromine in a Microreactor
Author(s) -
Deng Qiulin,
Shen Ruwei,
Ding Rong,
Zhang Lixiong
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201400723
Subject(s) - microreactor , reagent , halogenation , bromine , catalysis , chemistry , combinatorial chemistry , continuous flow , fluorescence , flow chemistry , organic chemistry , engineering , biochemical engineering , physics , quantum mechanics
2,4,5‐Trifluorobromobenzene is a valuable intermediate with important application in the synthesis of biologically active peptides and fluorescent reagents. A continuous‐flow system has been successfully developed for the synthesis of 2,4,5‐trifluorobromobenzene in a microreactor using FeBr 3 as a catalyst, which is steadily generated in situ from the reaction of Br 2 and Fe. The procedure is efficient and easy‐to‐handle, and 2,4,5‐trifluorobromobenzene can be obtained within minutes in high yields.