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Effect of Co‐Grinding on Crystallinity of Clopidogrel Bisulfate
Author(s) -
Mártha Csaba,
JójártLaczkovich Orsolya,
SzabóRévész Piroska
Publication year - 2014
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201400120
Subject(s) - crystallinity , grinding , thermogravimetric analysis , differential scanning calorimetry , amorphous solid , materials science , chemical engineering , strontium carbonate , chemistry , organic chemistry , metallurgy , composite material , physics , strontium , engineering , thermodynamics
A high energy input during pharmaceutical formulation is capable of decreasing the crystallinity of compounds in the product. The presence of the amorphous form can cause serious problems at any stage of the formulation. Crystallinity changes of a model powder mixture containing clopidogrel bisulfate (CLP) and a colloidal silicon dioxide as additive were investigated during a long‐time co‐grinding process. The crystallinity of CLP was reduced sigmoidally by co‐grinding with longer co‐grinding time. X‐ray powder diffraction and differential scanning calorimetry examinations confirmed that the product had become totally amorphous after four hours of grinding. Thermogravimetric results proved that no major mass reduction happened and FT‐IR changes referred to formulation of a secondary bond between the components.