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Knowledge‐Based Conceptual Synthesis of Industrial‐Scale Downstream Processes for Biochemical Products
Author(s) -
Backhaus Karin,
Lochmüller Mirka,
Arndt Markus Christian,
Riechert Ole,
Schembecker Gerhard
Publication year - 2015
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201400111
Subject(s) - downstream (manufacturing) , downstream processing , guideline , process (computing) , biochemical engineering , heuristic , computer science , process engineering , systems engineering , scale (ratio) , process management , manufacturing engineering , engineering , chemistry , operations management , artificial intelligence , chromatography , medicine , physics , pathology , quantum mechanics , operating system
A generic, knowledge‐based guideline assisting downstream process synthesis for biochemical products is presented. It offers process designers a structured process design methodology supporting them in capturing potentially relevant information, which might be beyond their expertise. The guideline is based on heuristic knowledge which was collected, structured in a generic way, and clearly represented. The generation of alternative downstream routes as starting points for experiments, simulation, and cost calculation is hereby accelerated. The application of the guideline is demonstrated on the example of penicillin V downstream processing from fermentation broth.