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Effect of Specific Amino Acids on Controlling Crystal Pseudopolymorphism of L ‐Arginine Hydrochloride
Author(s) -
Shimizu Takeshi,
Yoshiura Hiromu,
Nagano Hiroshi,
Hirasawa Izumi
Publication year - 2014
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201300695
Subject(s) - chemistry , hydrochloride , amino acid , arginine , aqueous solution , alkyl , stereochemistry , alanine , side chain , crystal (programming language) , organic chemistry , biochemistry , polymer , computer science , programming language
Abstract The effect of a small amount of amino acid additives on the pseudopolymorphism of L ‐arginine hydrochloride (LAHCL) in aqueous solution is reported. Results confirm that L ‐alanine ( L ‐Ala) has a stabilizing effect on the crystals of the anhydrate form of LAHCL at low temperature. Intriguingly, the stabilizing effect was observed even when L ‐Ala was added after a large amount of LAHCL had formed. In contrast, no stabilizing effect with D ‐Ala could be stated, suggesting that the stereochemistry of the additives is an important factor. In addition to the stereochemistry, also the length and bulkiness of the alkyl side‐chain of the amino acids were found to be significant factors. Based on these results, a mechanism is proposed for stabilization of anhydrate LAHCL crystals by amino acid additives.