Premium
Sterilization of Medical Products from Collagen by Means of Supercritical CO 2
Author(s) -
Herdegen Volker,
Felix Alexander,
Haseneder Roland,
Repke JensUwe,
LeppchenFröhlich Kathrin,
Prade Ina,
Meyer Michael
Publication year - 2014
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201300679
Subject(s) - sterilization (economics) , supercritical fluid , biocompatibility , materials science , supercritical carbon dioxide , chemical engineering , pulp and paper industry , biomedical engineering , waste management , chemistry , organic chemistry , medicine , metallurgy , business , engineering , finance , exchange rate , foreign exchange market
Collagen is increasingly used as material for medical devices because of its excellent biocompatibility. To achieve long‐term durability, the collagen materials are dried and subsequently sterilized. Most common sterilization methods are unsuitable as they cause denaturation. Currently, only ethylenoxide or γ irradiation preserves the microscopic and macroscopic collagen structure. However, both methods require high safety standards and include the risk of uncontrolled crosslinking or cleavage of protein chains. Here, supercritical carbon dioxide is used for the sterilization of different collagen devices. Thereby, the influence of pressure, temperature, sterilization aid and dosage, and different operation modes is determined. The method is a promising alternative to existing sterilization techniques.