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Coupled Continuous Chromatography and Racemization Processes for the Production of Pure Enantiomers
Author(s) -
Swernath Subramanian,
Kaspereit Malte,
Kienle Achim
Publication year - 2014
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201300597
Subject(s) - racemization , simulated moving bed , enantiomer , chemistry , chromatography , process engineering , solvent , organic chemistry , engineering , adsorption
Combining an enantioseparation by continuous chromatography with the racemization of the undesired enantiomer in a recycle is a promising approach. Two different cases were considered: limited conversion of the reaction with moderate product purity requirements and high conversion with high product purity requirements. For the first case, a simple plantwide control strategy is presented, manipulating the solvent removal in front of the racemization reactor. It is shown that the various disturbances can be compensated with this strategy without performing the more complex readjustment of the chromatographic unit. Further, it is shown that this strategy is likely to fail in the second scenario and that readjustment of the chromatographic unit is required for a successful control strategy.