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Population Balance Modeling of the Solution‐Mediated Transformation of DL ‐Methionine Polymorphs
Author(s) -
Wantha L.,
Flood A. E.
Publication year - 2013
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201300034
Subject(s) - dissolution , crystallization , nucleation , metastability , kinetics , population balance equation , population , thermodynamics , chemistry , crystallography , transformation (genetics) , materials science , chemical engineering , organic chemistry , physics , biochemistry , demography , quantum mechanics , sociology , gene , engineering
Experimental measurements of the solution‐mediated transformation (SMT) of the metastable polymorph of DL ‐methionine (α‐ DL ‐met) into the stable polymorph (γ‐ DL ‐met) in water were performed at 25 °C. These results were compared to models of the crystallization and the SMT of α‐ DL ‐met into γ‐ DL ‐met that were developed using the concept of the population balance equation (PBE) applied to both of the polymorphs. The growth, dissolution, and nucleation kinetic expressions obtained in a previous work were used in the models. It was found that the PBE models did not satisfactorily describe the SMT process of DL ‐met when the measured crystallization and dissolution kinetics were used. There were large mismatches between the simulation and the experimental results. Modifying the model of the dissolution kinetics of α‐ DL ‐met enabled these mismatches to be lowered. The results showed that the SMT of DL ‐met is controlled by the rate of dissolution of α‐ DL ‐met.