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Packed‐Bed Microreactor for Continuous‐Flow Adipic Acid Synthesis from Cyclohexene and Hydrogen Peroxide
Author(s) -
Shang M.,
Noël T.,
Wang Q.,
Hessel V.
Publication year - 2013
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201200703
Subject(s) - adipic acid , microreactor , cyclohexene , hydrogen peroxide , catalysis , yield (engineering) , packed bed , chemistry , solvent , chemical engineering , organic chemistry , materials science , chromatography , composite material , engineering
The synthesis of adipic acid by means of a direct oxidation of cyclohexene by hydrogen peroxide was carried out in a continuous‐flow packed‐bed microreactor. The reaction uses Na 2 WO 4 ·2H 2 O as a catalyst and [CH 3 ( n ‐C 8 H 17 ) 3 N]HSO 4 as a phase transfer catalyst without additional solvent. A parametric process optimization, such as glass beads size, residence time, concentration of hydrogen peroxide, addition of acid, reaction temperature, and molar ratios of reactants and catalysts, was performed. It is demonstrated that smaller glass beads result in a better yield of adipic acid and that the addition of acid plays an important role in the oxidation of cyclohexene to adipic acid. Based on the concept of Novel Process Windows, the influence of elevated temperatures is investigated.