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Solubility of Ibuprofen, Phytosterol, Salicylic Acid, and Naproxen in Aqueous Solutions
Author(s) -
Bolten D.,
Lietzow R.,
Türk M.
Publication year - 2013
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201200510
Subject(s) - naproxen , chemistry , solubility , salicylic acid , ibuprofen , stabilizer (aeronautics) , aqueous solution , chromatography , phytosterol , drug , diflunisal , pharmacology , organic chemistry , biochemistry , medicine , mechanical engineering , alternative medicine , pathology , engineering
Experimental solubility data of the nonsteroidal anti‐inflammatory drugs (NSAIDs) ibuprofen, salicylic acid, and naproxen as well as of the plant‐derived active component phytosterol have been determined in aqueous stabilizer solutions as a function of stabilizer concentration. SDS, Solutol® HS15, Tween® 20, Tween® 80, polidocanol, Lutrol® F68, PVP 10, PVP K25, and PVP K90 were chosen to solubilize the drugs. Furthermore, the influence of temperature, buffer, and pH value of the aqueous solution on drug solubility was investigated.