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Effect of Supersaturation and Thermodynamics on Co‐Crystal Formation
Author(s) -
Lee K.C.,
Kim K.J.
Publication year - 2011
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201000540
Subject(s) - supersaturation , crystallization , crystal (programming language) , ternary operation , phase diagram , thermodynamics , chemistry , methanol , crystal structure , crystallography , materials science , phase (matter) , organic chemistry , physics , computer science , programming language
Abstract Ternary solid‐liquid equilibrium diagrams of the system methanol/carbamazepine (CBZ)/nicotinamide (NCT) were generated and are discussed in the range between 5 and 50 °C. A study of the phase diagrams reveals that co‐crystals could successfully be prepared. An evaporative crystallization method was used to prepare the co‐crystals. By increasing the temperature, the co‐crystal solubilities increased. In most cases, the co‐crystals formed near room temperature. Regions for co‐crystal, CBZ + co‐crystal, NCT + co‐crystal, CBZ crystal, and NCT crystal formation, and for the saturated solution are visible in the ternary diagram. In the region of supersaturation of S > 2.2, co‐crystals were formed.