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New Crystalline Solvates of Atorvastatin Calcium
Author(s) -
Jin Y. S.,
Ulrich J.
Publication year - 2010
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200900571
Subject(s) - amorphous solid , crystallization , raman spectroscopy , atorvastatin , materials science , characterization (materials science) , crystallography , calcium , powder diffraction , polymorphism (computer science) , polarized light microscopy , chemical engineering , chemistry , nanotechnology , organic chemistry , metallurgy , optics , physics , engineering , medicine , biochemistry , genotype , gene , endocrinology
Atorvastatin calcium (ATC) is widely prescribed as a cholesterol‐lowering agent and is presently the world's best‐selling medicine. A large number of crystalline forms of ATC have been published in patents. In this work, two new crystalline solvates were discovered. Common crystallization methods were used to generate these forms from amorphous ATC. The following methods were applied for characterization: XRPD, DSC, TG, optical microscopy and FT‐Raman spectroscopy. The analytical results were distinct from those of the previously reported crystalline polymorphs, solvates and amorphous forms.