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Effect of Sonocrystallization on the Habit and Structure of Gemfibrozil Crystals
Author(s) -
Ambrus R.,
Amirzadi N. N.,
Sipos P.,
SzabóRévész P.
Publication year - 2010
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200900568
Subject(s) - gemfibrozil , economies of agglomeration , crystal habit , solubility , particle size , chemical engineering , amorphous solid , materials science , solvent , diffusion , particle (ecology) , chemistry , crystallography , organic chemistry , crystallization , thermodynamics , biochemistry , physics , oceanography , cholesterol , engineering , geology
Specially engineered drug particles can solve solubility and formulation problems, which are major challenges for the pharmaceutical industry. Ultrasound irradiation induces acoustic streaming, and highly localized temperature and pressure within the fluid, which can lead to a reduction in crystal size and the inhibition of agglomeration. This study covers properties inherent to particle engineering as well as methods for microparticle production and characterization. Melt emulsification and solvent diffusion using ultrasound to complete with drying are presented on the example of poorly water‐soluble Gemfibrozil. Differences in particle size were found depending on the processing parameters applied. During structural characterizations, strong interactions were detected between the drug and the stabilizers. Amorphous or crystalline Gemfibrozil could be obtained.