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Miniaturization of Pressure Filtration Processes for Lean Development
Author(s) -
Jermann S.,
Schreiner A.,
Schneeberger R.
Publication year - 2009
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200900062
Subject(s) - filtration (mathematics) , miniaturization , process engineering , process development , filter (signal processing) , scale (ratio) , mechanical engineering , engineering , materials science , mathematics , nanotechnology , physics , statistics , electrical engineering , quantum mechanics
As a basic operation of mechanical process engineering, pressure filtration and its scale‐up has been described in detail in the literature. But, the pharmaceutical development of active substances, in particular, calls for a scale‐up of relatively small quantities to execute downstream processes in a lean and reliable manner. Therefore, development depends on conclusions from smaller filter equipment. In this study, results from laboratory nutsche filters with filter surface areas of 1.4 cm 2 and 9.6 cm 2 were compared with results from a 20 cm 2 nutsche. It has been shown that no reproducible and reliable data could be generated using the 1.4‐cm 2 nutsche. While this was possible using the 9.6 cm 2 nutsche, the permeability was greater than with the recommended 20 cm 2 nutsche so that a correction factor has to be introduced.