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Microreactor for Synthesis Via Intermediates with Assembled Units Enabling Rapid Operations
Author(s) -
Aoki N.,
Kitajima R.,
Itoh C.,
Mae K.
Publication year - 2008
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200800106
Subject(s) - microreactor , mixing (physics) , chemistry , yield (engineering) , flow chemistry , heat transfer , continuous reactor , residence time (fluid dynamics) , selectivity , bromobenzene , batch reactor , plug flow reactor model , chemical engineering , materials science , continuous stirred tank reactor , organic chemistry , thermodynamics , catalysis , physics , geotechnical engineering , quantum mechanics , engineering , metallurgy
This paper describes a reactor for multistep syntheses via intermediates with improved selectivity of the desired product. This reactor is referred to as an assembled reactor. It consists of mixing, residence time, and heat exchange units. Connection of these units forms a module for a single reaction. Repeated joints of these modules enable the reactor to be used in multistep syntheses. Mixing and the heat transfer rate of the assembled reactor were evaluated. This reactor enabled rapid mixing under the total flow rates of more than 30 mL/min and heat transfer efficiency of the order of 10 K per 10 ms in the heat exchange of fluids with a temperature difference of 20–40 K. This reactor was also applied to the synthesis of bromobenzene via p ‐bromophenyllithium and gave a product yield of more than 80 %.