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Nucleation and Supersaturation in Drowning‐Out Crystallization using a T‐Mixer
Author(s) -
Kim K.J.,
Kim J.K.
Publication year - 2006
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200600081
Subject(s) - supersaturation , crystallization , nucleation , homogeneous , particle size , materials science , solvent , chemical engineering , particle (ecology) , thermodynamics , chemistry , physics , organic chemistry , engineering , oceanography , geology
In order to assess the performance of drowning‐out crystallization using a T‐mixer, nucleation and supersaturation were studied. The particle size was changed considerably with the solvent fraction and the feed rate, which were the main parameters controlling the supersaturation. At S = 1.7, the boundary point between homogeneous and heterogeneous nucleations was found from a log‐log plot of supersaturation rate versus maximum supersaturation. Drowning‐out crystallization using a T‐mixer could easily generate high supersaturations of up to 50, which were adjusted by the feed rate and the ratio of solvent to antisolvent. Nano‐ and micron‐sized particles can be prepared by drowning‐out crystallization using a T‐mixer.