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Factors Affecting the Polymorphic Outcome of Glycine Crystals Constrained on Patterned Substrates
Author(s) -
Lee A. Y.,
Lee I. S.,
Myerson A. S.
Publication year - 2006
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200500375
Subject(s) - monolayer , crystallization , nucleation , glycine , evaporation , materials science , chemical engineering , metal , solvent , morphology (biology) , nanotechnology , crystallography , chemical physics , chemistry , organic chemistry , amino acid , thermodynamics , metallurgy , biochemistry , physics , genetics , biology , engineering
The primary goal of crystallization process is to generate particles with controlled size, shape and solid form, and the desired chemical purity. Many different types of approaches including molecular level strategies have been devised and employed to control the final structure of crystals. One promising approach is the utilization of self‐assembled monolayers (SAMs) as templates. Recently, we reported that single glycine crystals can nucleate on patterned metallic square islands, with the size and morphology of the particles controlled by the dimensions of the islands or the concentration of the solution. Herein, the effect of the solution concentration on the polymorphic outcome of glycine crystals confined to hydrophilic metallic islands is investigated. Furthermore, we examine how variations in the solvent evaporation rate can impact the polymorph distribution of glycine.