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Influence of Crystallization Conditions on Rheology and Microstructure of Dense Suspensions of Crystals of Eflucimibe
Author(s) -
Teychene S.,
Autret J. M.,
Biscans B.
Publication year - 2006
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.200500374
Subject(s) - crystallization , materials science , rheology , volume fraction , suspension (topology) , elastic modulus , viscoelasticity , particle (ecology) , microstructure , volume (thermodynamics) , thermodynamics , chemical engineering , composite material , oceanography , physics , mathematics , homotopy , pure mathematics , engineering , geology
The crystallization process of eflucimibe, a new ACAT inhibitor, was carried out in a mixture of two solvents, ethanol and n‐heptane, by cooling. During the process, as the volume fraction of crystals was raised, the suspension went towards a very structured gel‐like network. This phenomenon acts as a brake to the extrapolation of the process. Experiments were carried out in a glass double‐jacketed 750 mL reactor in a LABMAX controlled system. At the end of the crystallization, rheological flow characteristics at constant ambient temperature were determined. The samples behave like a plastic fluid. The evolution of the elastic and viscous moduli as a function of the applied strain for a given oscillation frequency was measured. The results showed that the variation of the elastic modulus with particle concentration follows a power law. It was shown that for particle concentration higher than 2 % (volume fraction) needle‐like growing crystals form a network in which solvent is trapped.