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Recent Developments and Challenges for the Industrial Implementation of Polyphosphate Kinases
Author(s) -
Tavanti Michele,
Hosford Joseph,
Lloyd Richard C.,
Brown Murray J. B.
Publication year - 2021
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202100688
Subject(s) - polyphosphate , kinase , biochemical engineering , business , chemistry , risk analysis (engineering) , nanotechnology , phosphate , biochemistry , engineering , materials science
Polyphosphate kinases (PPKs) have emerged as valuable candidates to address the unmet need for scalable recycling of the common enzyme cofactor adenosine‐5’‐triphosphate (ATP) because they use cheap, freely available and stable polyphosphate (polyP) salts as the phosphate donor. The aim of this review is not only to present recent efforts in the characterisation of PPKs but also to provide an overview of the challenges associated with their implementation in chemical manufacturing. In assessing the current status of polyP‐driven biocatalysts, we identify gaps that need to be filled for successful adoption of these biocatalysts in industry. Guidelines for a wider adoption of PPKs are also provided.