Time‐Economical Synthesis of Diarylacetates Enabled by TfOH‐Catalyzed Arylation of  α ‐Aryl‐ α ‐Diazoesters with Arenes | Zendy

Hu Sha | Zendy; Wu Jiale | Zendy; Lu Zuolin | Zendy; Wang Jiaqi | Zendy; Tao Yuan | Zendy; Jiang Meifen | Zendy; Chen Fener | Zendy

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Time‐Economical Synthesis of Diarylacetates Enabled by TfOH‐Catalyzed Arylation of α ‐Aryl‐ α ‐Diazoesters with Arenes

Author(s) -

Hu Sha,

Wu Jiale,

Lu Zuolin,

Wang Jiaqi,

Tao Yuan,

Jiang Meifen,

Chen Fener

Publication year - 2021

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.202100271

Subject(s) - chemistry , aryl , catalysis , combinatorial chemistry , organic chemistry , reaction conditions , alkyl

Diarylacetates are privileged structures of many bioactive natural products and pharmaceutical compounds. A time‐economical synthesis of diarylacetates by TfOH‐catalyzed arylation of α ‐aryl‐ α ‐diazoesters with arenes is described. This protocol provides a variety of diarylacetates in good yields with broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Also, a new mechanism for the arylation reaction of α ‐aryl‐ α ‐diazoesters with arenes under TfOH catalysis is presented.

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