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Time‐Economical Synthesis of Diarylacetates Enabled by TfOH‐Catalyzed Arylation of α ‐Aryl‐ α ‐Diazoesters with Arenes
Author(s) -
Hu Sha,
Wu Jiale,
Lu Zuolin,
Wang Jiaqi,
Tao Yuan,
Jiang Meifen,
Chen Fener
Publication year - 2021
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202100271
Subject(s) - chemistry , aryl , catalysis , combinatorial chemistry , organic chemistry , reaction conditions , alkyl
Diarylacetates are privileged structures of many bioactive natural products and pharmaceutical compounds. A time‐economical synthesis of diarylacetates by TfOH‐catalyzed arylation of α ‐aryl‐ α ‐diazoesters with arenes is described. This protocol provides a variety of diarylacetates in good yields with broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Also, a new mechanism for the arylation reaction of α ‐aryl‐ α ‐diazoesters with arenes under TfOH catalysis is presented.