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Cover Feature: Multi‐faceted Set‐up of a Diverse Ketoreductase Library Enables the Synthesis of Pharmaceutically‐relevant Secondary Alcohols (6/2021)
Author(s) -
Voss Moritz,
Küng Robin,
Hayashi Takahiro,
Jonczyk Magdalena,
Niklaus Michael,
Iding Hans,
Wetzl Dennis,
Buller Rebecca
Publication year - 2021
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202100215
Subject(s) - cover (algebra) , combinatorial chemistry , set (abstract data type) , computational biology , feature (linguistics) , enzyme , function (biology) , solid phase synthesis , chemistry , computer science , nanotechnology , biochemistry , biology , materials science , engineering , programming language , genetics , mechanical engineering , linguistics , philosophy , peptide
The Cover Feature highlights the synthetic potential of a diverse, off‐the‐shelf ketoreductase library for the selective reduction of small molecule ketones. In their Full Paper, M. Voss, R. Küng et al. present the multi‐faceted set‐up of a diverse ketoreductase library and demonstrate the use of 51 enzymes for the synthesis of valuable building blocks. Linking function with the respective protein sequences enabled the assignment of amino acid patterns to the observed enantioselectivities. The availability of this ready‐to‐screen enzyme library, including 29 novel ketoreductases, is expected to accelerate the implementation of biocatalytic steps in industrial processes and to guide further enzyme sourcing campaigns. (Created with BioRender.com).More information can be found in the Full Paper by M. Voss, R. Küng et al.