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Late‐stage Pd‐catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media
Author(s) -
Thakore Ruchita R.,
Takale Balaram S.,
Singhania Vani,
Gallou Fabrice,
Lipshutz Bruce H.
Publication year - 2021
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202001742
Subject(s) - halide , aryl , aqueous medium , catalysis , chemistry , combinatorial chemistry , aqueous solution , molecule , organic chemistry , pulmonary surfactant , micelle , palladium , alkyl , biochemistry
New technology is described that enables late stage ppm Pd‐catalyzed cyanations of highly complex molecules, as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a commercially available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.