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Cover Feature: In Vivo Reduction of Medium‐ to Long‐Chain Fatty Acids by Carboxylic Acid Reductase (CAR) Enzymes: Limitations and Solutions (ChemCatChem 20/2020)
Author(s) -
Horvat Melissa,
Winkler Margit
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202001505
Subject(s) - aldehyde , biocatalysis , cofactor , enzyme , carboxylic acid , fatty acid , chemistry , biochemistry , aldehyde reductase , reductase , organic chemistry , catalysis , reaction mechanism
The Cover Feature shows a woman who is enjoying a fragrance that was produced by a biocatalyst from a fatty acid. In their Full Paper, M. Horvat and M. Winkler explain how carboxylic acid reductases can be utilized as the key enzyme for aldehyde preparation in a whole cell system despite a number of challenges related to both the enzyme and the host organism. The key elements in the optimization were improvement of post‐translational modification, in‐situ product removal and the support of cofactor supply by an ex‐cell recycling system. This systematic investigation for medium‐to long‐chain fatty aldehyde production led to an approximate 16.6 times increase in productivity while using 10 times less biocatalyst. More information can be found in the Full Paper by M. Horvat and M. Winkler.