Premium
A Ring Closing Metathesis Approach to the Formal Synthesis of (+)‐Callyspongiolide
Author(s) -
Ko KwangYoon,
Wilson Zoe E.,
Furkert Daniel P.,
Brimble Margaret A.
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202001139
Subject(s) - ring closing metathesis , metathesis , formal synthesis , enantioselective synthesis , natural product , ring (chemistry) , combinatorial chemistry , chemistry , salt metathesis reaction , core (optical fiber) , total synthesis , stereochemistry , organic chemistry , catalysis , materials science , polymerization , composite material , polymer
An enantioselective synthesis of macrocyclic core of (+)‐callyspongiolide is described, constituting a formal synthesis of this natural product. The synthetic strategy constructs the 14‐membered macrocyclic domain via Yamaguchi esterification followed by a challenging ring‐closing metathesis (RCM) to effect the final formation of the macrolactone.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom