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A Ring Closing Metathesis Approach to the Formal Synthesis of (+)‐Callyspongiolide
Author(s) -
Ko KwangYoon,
Wilson Zoe E.,
Furkert Daniel P.,
Brimble Margaret A.
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202001139
Subject(s) - ring closing metathesis , metathesis , formal synthesis , enantioselective synthesis , natural product , ring (chemistry) , combinatorial chemistry , chemistry , salt metathesis reaction , core (optical fiber) , total synthesis , stereochemistry , organic chemistry , catalysis , materials science , polymerization , composite material , polymer
Abstract An enantioselective synthesis of macrocyclic core of (+)‐callyspongiolide is described, constituting a formal synthesis of this natural product. The synthetic strategy constructs the 14‐membered macrocyclic domain via Yamaguchi esterification followed by a challenging ring‐closing metathesis (RCM) to effect the final formation of the macrolactone.