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Cu/PCy 3 ‐Catalyzed Formal Carbene Insertion into Electron‐Deficient C−H Bonds
Author(s) -
Ren YuanYuan,
Mao HongXiang,
Hu MengYang,
Zhu ShouFei,
Zhou QiLin
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000684
Subject(s) - carbene , cyclopropanation , chemistry , catalysis , ring (chemistry) , insertion reaction , migratory insertion , formal synthesis , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry
A carbene insertion into electron‐deficient C−H bonds of 1,3‐diesters, β‐ketoesters, β‐ketonitriles, and malononitriles was realized by using CuCN/PCy 3 as the catalyst. The reaction provides a straightforward approach to the synthetically important multi‐substituted succinic acid derivatives. A plausible reaction mechanism with cyclopropanation/ring opening as key steps was proposed based on control experiments.
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