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Palladium‐Catalyzed Decarboxylative Three‐Component Synthesis of α‐Arylglycines: Replacing Boronic with Carboxylic Acids in the Petasis Reaction
Author(s) -
Diehl Andreas M.,
Manolikakes Georg
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000652
Subject(s) - chemistry , palladium , glyoxylic acid , catalysis , nucleophile , organic chemistry , benzoic acid , boronic acid , component (thermodynamics) , combinatorial chemistry , physics , thermodynamics
A palladium‐catalyzed three‐component synthesis of α‐arylglycines from benzoic acids, sulfonamides and glyoxylic acid is reported. This novel reaction offers straightforward access to the important arylglycine motif in good yields and high structural diversity. By replacing boronic with carboxylic acids as nucleophilic component, this method can be considered as a more sustainable version of the classical Petasis reaction for synthesis of arylglycines.