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Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2 H ‐Chromenes
Author(s) -
Yang Qingjing,
Li Sifeng,
Wang Jun Joelle
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000601
Subject(s) - hydroamination , enantioselective synthesis , hydroxylamine , chemistry , copper , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry
A copper/( R )‐DTBM‐SEGPHOS‐catalyzed enantioselective hydroamination of 2 H ‐chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4‐aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions.