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Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)‐Catalyzed Indole 2‐Methylenephosphorylation
Author(s) -
Niu Yuan,
Bai PengBo,
Lou QinXin,
Yang ShangDong
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000415
Subject(s) - synthon , indole test , chemistry , phosphonate , palladium , catalysis , methylene , combinatorial chemistry , indole alkaloid , organic chemistry
A palladium‐catalyzed Catellani‐type reaction of indole with diethyl (iodomethyl)phosphonate has been developed. This new protocol provides an efficient and concise route to 2‐methylene phosphonate indoles, which are key synthons for the construction of indole alkaloids.