Premium
Two Simple and Highly Efficient Variants of the Griffith‐Ley Oxidation of Alcohols
Author(s) -
Weingart Pascal,
Hütchen Patrick,
Damone Angelo,
Kohns Maximilian,
Hasse Hans,
Thiel Werner R.
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000413
Subject(s) - ruthenium , catalysis , alcohol oxidation , chemistry , trimethylamine , solvent , heptane , alcohol , ruthenium oxide , oxide , organic chemistry , medicinal chemistry
The Griffith‐Ley oxidation of alcohols to aldehydes and ketones is performed with either RuCl 3 ⋅ (H 2 O) x or a highly stable, well‐defined ruthenium catalyst and with cheap trimethylamine N ‐oxide (TMAO) as the oxygen source. The use of n ‐heptane as the solvent, which forms a second phase with TMAO and a part of the alcohol, allows the reactions to be performed with a minimum amount of catalyst. This results in high local concentrations and thus to very rapid conversions. Detailed quantum chemical calculations suggest, that the Griffith‐Ley oxidation not necessarily requires high oxidation states of ruthenium but can also proceed with Ru II /Ru IV species.