Lipase‐oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of  sec ‐alcohols | Zendy

De Almeida Laiza A. | Zendy; Marcondes Thayna H. | Zendy; Milagre Cintia D. F. | Zendy; Milagre Humberto M. S. | Zendy

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Lipase‐oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec ‐alcohols

Author(s) -

De Almeida Laiza A.,

Marcondes Thayna H.,

Milagre Cintia D. F.,

Milagre Humberto M. S.

Publication year - 2020

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.202000292

Subject(s) - kinetic resolution , catalysis , chemistry , substrate (aquarium) , enantioselective synthesis , heterogeneous catalysis , lipase , heptane , organic chemistry , candida antarctica , combinatorial chemistry , enzyme , oceanography , geology

Herein, we present a robust and eco‐friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL−B/VOSO 4 system at 50 °C in the relatively green solvent heptane. This catalytic system is active and chemo‐ and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcohols were evaluated to determine the substrate scope. The performance of the combined CAL−B/VOSO 4 system was improved by employing a low‐cost, homemade Teflon tube to compartmentalize the catalysts in one‐pot conditions, making this system for up to 8 reaction cycles.

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