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Lipase‐oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec ‐alcohols
Author(s) -
De Almeida Laiza A.,
Marcondes Thayna H.,
Milagre Cintia D. F.,
Milagre Humberto M. S.
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000292
Subject(s) - kinetic resolution , catalysis , chemistry , substrate (aquarium) , enantioselective synthesis , heterogeneous catalysis , lipase , heptane , organic chemistry , candida antarctica , combinatorial chemistry , enzyme , oceanography , geology
Herein, we present a robust and eco‐friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL−B/VOSO 4 system at 50 °C in the relatively green solvent heptane. This catalytic system is active and chemo‐ and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcohols were evaluated to determine the substrate scope. The performance of the combined CAL−B/VOSO 4 system was improved by employing a low‐cost, homemade Teflon tube to compartmentalize the catalysts in one‐pot conditions, making this system for up to 8 reaction cycles.