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Fabrication of Copper‐based Silica‐coated Magnetic Nanocatalyst for Efficient One‐pot Synthesis of Chalcones via A 3 Coupling of Aldehydes‐Alkynes‐Amines
Author(s) -
Yadav Priya,
Yadav Manavi,
Gaur Rashmi,
Gupta Radhika,
Arora Gunjan,
Rana Pooja,
Srivastava Anju,
Sharma Rakesh K.
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.202000148
Subject(s) - chalcone , catalysis , aldehyde , chemistry , one pot synthesis , solvent , combinatorial chemistry , organic chemistry
In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica‐coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility for the solvent‐free one‐pot synthesis of chalcone moieties by A 3 coupling of aldehydes‐alkynes‐amines in good to excellent yields. The fabricated Cu@DBM@ASMNPs was structurally and chemically analyzed by various techniques such as FT‐IR, SEM, TEM, VSM, ICP‐MS, ED‐XRF and XPS. The programmed catalytic protocol has been proceeded via isomerization‐hydrolysis reaction of aldehydes and terminal alkynes. The present strategy offered much greener and efficacious synthesis of chalcones by adding benefits such as solvent‐less synthetic protocol and much shorter reaction time. Other interesting and noteworthy features of this methodology are broad substrate scope, mild reaction conditions, and reusability up to seven runs without significant loss of its catalytic activity which renders it an environmentally friendly and remarkable protocol from industrial point of view.