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Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase‐Catalysed In Situ Generation of H 2 O 2
Author(s) -
Schie Morten M. C. H.,
Kaczmarek Alexander T.,
Tieves Florian,
Gomez de Santos Patricia,
Paul Caroline E.,
Arends Isabel W. C. E.,
Alcalde Miguel,
Schwarz Günter,
Hollmann Frank
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201902297
Subject(s) - sulfite , chemistry , sulfite oxidase , oxygen , hydrogen peroxide , catalysis , flue gas , redox , combinatorial chemistry , photochemistry , inorganic chemistry , organic chemistry
Abstract H 2 O 2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio‐ and regio‐selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H 2 O 2 , however, requires this oxidant to be generated in situ . Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts.