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Enantiotopic Discrimination by Coordination‐Desymmetrized meso ‐Ligands
Author(s) -
Li Yutang,
Lidskog Anna,
ArmengolRelats Helena,
Pham Thanh Huong,
Favraud Antoine,
Nicolas Maxime,
Dawaigher Sami,
Xiao Zeyun,
Ma Dayou,
Lindbäck Emil,
Strand Daniel,
Wärnmark Kenneth
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201902243
Subject(s) - enantiopure drug , catalysis , chemistry , ligand (biochemistry) , ring (chemistry) , ion , combinatorial chemistry , stereochemistry , coordination complex , metal , enantioselective synthesis , organic chemistry , receptor , biochemistry
The first examples of enantiopure catalysts that are chiral merely due to coordination of different metal ions at enantiotopic positions of an achiral meso ‐ligand are reported. These catalysts exhibit a pseudo‐ C s symmetry and are able to catalyze reactions demanding simultaneous involvement of two catalytic sites. The latter was demonstrated by application in the asymmetric ring‐opening of meso ‐epoxides.