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Front Cover: Accessing the Biocatalytic Potential for C−H‐Activation by Targeted Genome Mining and Screening (ChemCatChem 23/2019)
Author(s) -
Schmitz Lisa Marie,
Schäper Jonas,
Rosenthal Katrin,
Lütz Stephan
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201902102
Subject(s) - front cover , biotransformation , catalysis , protein data bank (rcsb pdb) , biocatalysis , chemistry , cover (algebra) , heme , genome , stereochemistry , computational biology , combinatorial chemistry , reaction mechanism , biochemistry , enzyme , biology , gene , engineering , mechanical engineering
The Front Cover shows a C−H‐activation reaction carried out by the heme group (orange) of a protein (PDB: 1000). In their Full Paper, Stephan Lütz and co‐workers present the successful identification of novel and versatile P450 biocatalysts by genome mining and its successful scale‐up to a biotransformation reaction on L‐scale. The results show that a large number of catalysts for C−H‐activation is still undiscovered and holds the promise to find more useful catalysts for green oxidation processes. More information can be found in the Full Paper by Lisa Marie Schmitz et al. on page 5766 in Issue 23, 2019 (DOI: 10.1002/cctc.201901273).