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Recombinant Peptide Fusion Protein‐Templated Palladium Nanoparticles for Suzuki‐Miyaura and Stille Coupling Reactions
Author(s) -
Mosleh Imann,
Shahsavari Hamid R.,
Beitle Robert,
Beyzavi M. Hassan
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201902099
Subject(s) - stille reaction , green fluorescent protein , chemistry , nanoparticle , combinatorial chemistry , peptide , palladium , solvent , coupling reaction , catalysis , organic chemistry , nanotechnology , biochemistry , materials science , gene
This study examined the use of nanoparticles created with recombinant 45‐amino acid long peptides fused to green fluorescent protein (GFPuv) to catalyze twelve representative Suzuki‐Miyaura and Stille coupling reactions. A method was developed to prepare powders (Pd@GFP) containing protein and synthesized nanoparticles. Next, coupling reactions were performed in a green solvent without nanoparticle purification. Pd@GFP had high turnover frequencies for the synthesis of model compounds including lapatinib (Tykerb®) and could be recycled. This study establishes a potentially cost‐effective approach to prepare heterogeneous catalysts containing well‐defined nanoparticles enabling key C−C bond formation leading to synthetically and pharmaceutically interesting compounds.