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Heterogeneous Manganese‐Catalyzed Oxidase C−H/C−O Cyclization to Access Pharmaceutically Active Compounds
Author(s) -
Ferlin Francesco,
Marini Alberto,
Ascani Nicola,
Ackermann Lutz,
Lanari Daniela,
Vaccaro Luigi
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201901659
Subject(s) - manganese , catalysis , chemistry , combinatorial chemistry , substrate (aquarium) , leaching (pedology) , heterogeneous catalysis , oxidase test , environmentally friendly , enzyme , organic chemistry , ecology , oceanography , environmental science , biology , soil science , soil water , geology
Heterogeneous manganese‐catalyzed C−H oxidative couplings were accomplished to gain access to pharmaceutically relevant 2‐aminophenoxazin‐3‐ones and to diaminophenazine and purpurogallin moieties in excellent yields. The user‐friendly K‐OMS‐2 oxidase strategy proved to be more versatile and robust than enzymatic catalysts‐based procedures allowing a wider substrate scope and being effectively reusable as proven by leaching measurements and XRD analyses.