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Reductive Amidation without an External Hydrogen Source Using Rhodium on Carbon Matrix as a Catalyst
Author(s) -
Tsygankov Alexey A.,
Makarova Maria,
Afanasyev Oleg I.,
Kashin Alexey S.,
Naumkin Alexander V.,
Loginov Dmitry A.,
Chusov Denis
Publication year - 2020
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201901465
Subject(s) - rhodium , catalysis , chemistry , carbon monoxide , hydrogen , benzamide , carbon fibers , heterogeneous catalysis , matrix (chemical analysis) , combinatorial chemistry , organic chemistry , materials science , composite number , composite material , chromatography
An efficient method for preparation of secondary amides from primary amides and aldehydes using rhodium on carbon matrix as catalyst was developed. The method does not require any external hydrogen source and carbon monoxide is used as a reducing agent. The most active rhodium catalysts were characterized by BET, TEM and XPS techniques. Unexpectedly, it was found that heterogeneous rhodium on carbon matrix works as precatalyst for homogenous active species due to leaching of rhodium to the solution. Various secondary amides were synthesized and checked for antifungal activity. 4‐Methoxy‐N‐(4‐methoxybenzyl)benzamide demonstrated promising activity against Rhizoctonia Solani .