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Enhancing Ligand‐Free Fe‐Catalyzed Aminocarbonylation of Alkynes by ZrF 4
Author(s) -
Huang Zijun,
Dong Yanan,
Li Yudong,
Makha Mohamed,
Li Yuehui
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900995
Subject(s) - catalysis , amine gas treating , alkyne , chemistry , fluoride , ligand (biochemistry) , zirconium , combinatorial chemistry , organic chemistry , inorganic chemistry , biochemistry , receptor
Zirconium fluoride was utilized to promote efficiently iron‐catalyzed aminocarbonylation between alkynes and amines without the use of extra ligands. In particular, this new system is applicable to a wide range of amine and alkyne substrates affording α , β ‐unsaturated amides in good to excellent yields. Preliminary mechanistic studies reveal the activation model involving interactions of ZF 4 with both iron catalyst and amine substrates.