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Silver‐Induced [3+2] Cycloaddition of Isocyanides with Acyl Chlorides: Regioselective Synthesis of 2,5‐Disubstituted Oxazoles
Author(s) -
Liu JianQuan,
Shen Xuanyu,
Shatskiy Andrey,
Zhou Enlong,
Kärkäs Markus D.,
Wang XiangShan
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900965
Subject(s) - cycloaddition , regioselectivity , yield (engineering) , catalysis , chemistry , combinatorial chemistry , transition metal , organic chemistry , materials science , metallurgy
Abstract A silver‐induced cycloaddition of isocyanides with acyl chlorides has been developed. This transition metal‐catalyzed strategy provides an effective and scalable approach for the formation of 2,5‐disubstituted oxazoles in good to high yields. The employed silver‐based MOF catalyst can be efficiently recycled without compromising the yield.