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Copper‐Assisted Synthesis of Novel Pyrazolo[3,4‐ d ]thiazoles
Author(s) -
Ostache NicuCosmin,
Hiebel MarieAude,
Fînaru AdrianaLuminiţa,
Guillaumet Gérald,
Suzenet Franck
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900707
Subject(s) - intramolecular force , copper , thiazole , combinatorial chemistry , palladium , pyrazole , chemistry , catalysis , molecule , organic chemistry
Based on both the chemical and the biological importance of the pyrazole and the thiazole backbones, we report herein a convenient design of new pyrazolo[3,4‐ d ]thiazoles for the development of molecules with a high therapeutic potential. The effective and appropriate strategy chosen consists of an intramolecular copper‐catalysed N ‐arylation followed by the Liebeskind‐Srogl cross‐coupling reaction. The efficiency of copper and palladium catalysts for the first step of the synthesis was evaluated. These efforts allowed the synthesis of a variety of modulated heterobicycles.