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Diaryl Prolinols in Stereoselective Catalysis and Synthesis: An Update
Author(s) -
Meninno Sara,
Volpe Chiara,
Lattanzi Alessandra
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900569
Subject(s) - stereoselectivity , chemistry , catalysis , heteroatom , combinatorial chemistry , organocatalysis , enantioselective synthesis , reagent , covalent bond , organic chemistry , ring (chemistry)
Discovered more than one decade ago, α,α‐diaryl prolinols, most of them commercially available compounds, demonstrated to be distinctive organocatalysts in asymmetric synthesis. Their application successfully spanned across different carbon‐carbon or carbon‐heteroatom bond forming reactions and cascade processes, exploiting covalent and noncovalent activation of the reagents. In this minireview, the advances from 2013 up to the end of 2018 in α,α‐diaryl prolinols promoted stereoselective catalysis and synthesis of biologically active compounds, are illustrated.