Identification of an Oxalamide Ligand for Copper‐Catalyzed C−O Couplings from a Pharmaceutical Compound Library | Zendy

Chan Vincent S. | Zendy; Krabbe Scott W. | Zendy; Li Changfeng | Zendy; Sun Lijie | Zendy; Liu Yue | Zendy; Nett Alex J. | Zendy

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Identification of an Oxalamide Ligand for Copper‐Catalyzed C−O Couplings from a Pharmaceutical Compound Library

Author(s) -

Chan Vincent S.,

Krabbe Scott W.,

Li Changfeng,

Sun Lijie,

Liu Yue,

Nett Alex J.

Publication year - 2019

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201900393

Subject(s) - ligand (biochemistry) , combinatorial chemistry , copper , catalysis , chemistry , high throughput screening , drug discovery , thiophene , identification (biology) , stereochemistry , organic chemistry , receptor , biology , biochemistry , botany

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N , N’ ‐bis(thiophene‐2‐ylmethyl)oxalamide as a ligand that is generally effective for copper‐catalyzed C−O cross‐couplings to prepare both biarylethers as well as phenols under mild conditions.

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