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Identification of an Oxalamide Ligand for Copper‐Catalyzed C−O Couplings from a Pharmaceutical Compound Library
Author(s) -
Chan Vincent S.,
Krabbe Scott W.,
Li Changfeng,
Sun Lijie,
Liu Yue,
Nett Alex J.
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900393
Subject(s) - ligand (biochemistry) , combinatorial chemistry , copper , catalysis , chemistry , high throughput screening , drug discovery , thiophene , identification (biology) , stereochemistry , organic chemistry , receptor , biology , biochemistry , botany
A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N , N’ ‐bis(thiophene‐2‐ylmethyl)oxalamide as a ligand that is generally effective for copper‐catalyzed C−O cross‐couplings to prepare both biarylethers as well as phenols under mild conditions.