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Manganese‐Catalyzed ortho‐ Alkenylation of Aromatic Amidines with Alkynes via C−H Activation
Author(s) -
Jia Teng,
Wang Congyang
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900387
Subject(s) - manganese , catalysis , chemistry , selectivity , combinatorial chemistry , transformation (genetics) , medicinal chemistry , organic chemistry , biochemistry , gene
The first ortho ‐alkenylation of aromatic amidines with alkynes was realized by earth‐abundant manganese catalysis through C−H activation. A catalytic amount of PhMgBr was found essential for improved efficiency of this transformation. Wide tolerance of functional groups and excellent E / Z selectivity highlighted the current protocol.