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A Free‐Radical Reduction and Cyclization of Alkyl Halides Mediated by FeCl 2
Author(s) -
Pulikottil Feba Thomas,
Pilli Ramadevi,
Murugesan Vetrivelan,
Krishnan Chandu G.,
Rasappan Ramesh
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900230
Subject(s) - halide , alkyl , chemistry , catalysis , zinc , radical , radical initiator , hydrogen , functional group , radical cyclization , medicinal chemistry , organic chemistry , combinatorial chemistry , photochemistry , polymerization , polymer
Iron mediated catalytic reactions are of great interest in the field of organic synthesis because they are economic and naturally abundant. However, the use of iron catalyst in the field of free radical cyclization or reduction of alkyl halides remains limited. Here we describe the use of an unprecedented combination of iron and zinc in the reduction and 5‐ exo‐trig radical cyclization of alkyl halides under mild condition in the absence of added ligands or additives. The method is distinguished by its wide scope, functional group tolerance and the use of 1,4‐cyclohexadiene as the source of hydrogen, which aids easy purification.