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An Efficient, Scalable and Eco‐friendly Synthesis of 4,5‐substituted Pyrrole‐3‐Carbonitriles by Intramolecular Annulation on Pd/C and HZSM‐5
Author(s) -
Chen Jianchao,
Li Chengtao,
Zhou Yanan,
Sun Changshan,
Sun Tiemin
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900154
Subject(s) - reusability , annulation , environmentally friendly , intramolecular force , catalysis , yield (engineering) , pyrrole , combinatorial chemistry , chemistry , protocol (science) , organic chemistry , computer science , materials science , programming language , ecology , software , metallurgy , biology , medicine , alternative medicine , pathology
An efficient and eco‐friendly protocol for the synthesis of diverse 4,5‐substituted 1H‐pyrrole‐3‐carbonitriles has been developed using commercially available HZSM‐5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work‐up, eco‐friendly and reusability of catalysts.