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Chloramphenicol Base: A New Privileged Chiral Scaffold in Asymmetric Catalysis
Author(s) -
Xiao YouCai,
Chen FenEr
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900150
Subject(s) - bifunctional , catalysis , chemistry , oxazoline , combinatorial chemistry , ligand (biochemistry) , chloramphenicol , enantioselective synthesis , schiff base , base (topology) , organic chemistry , stereochemistry , biochemistry , antibiotics , receptor , mathematical analysis , mathematics
This Minireview focuses on the synthetic application of a chloramphenicol base (ANP)‐derived catalyst. In the illustrated examples, ANP derivatives have proven to be readily available and highly versatile catalysts in a wide range of asymmetric transformations, showing high proficiency as both chiral ligands (amino alcohol, Schiff base and oxazoline‐containing ligand) and organocatalyst (hydrogen bonding‐based bifunctional catalyst and phase transfer catalyst).