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Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients
Author(s) -
Cirujano Francisco G.
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900131
Subject(s) - biocatalysis , metal organic framework , organic synthesis , chemistry , biochemical engineering , combinatorial chemistry , synthetic biology , nanotechnology , catalysis , organic chemistry , materials science , computational biology , biology , engineering , reaction mechanism , adsorption
The latest strategies in the design and synthesis of metal‐organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions that are both chemo‐ and bio‐ catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost‐efficient manner, are thoroughly discussed in this mini review.