Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates | Zendy

Lutter Ferdinand H. | Zendy; Graßl Simon | Zendy; Grokenberger Lucie | Zendy; Hofmayer Maximilian S. | Zendy; Chen YiHung | Zendy; Knochel Paul | Zendy

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Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates

Author(s) -

Lutter Ferdinand H.,

Graßl Simon,

Grokenberger Lucie,

Hofmayer Maximilian S.,

Chen YiHung,

Knochel Paul

Publication year - 2019

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201900070

Subject(s) - cobalt , electrophile , catalysis , negishi coupling , chemistry , reagent , combinatorial chemistry , palladium , transition metal , organic chemistry

Transition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a useful alternative to other common metal‐catalysts (e. g. palladium‐complexes). In this review, we report that cobalt‐catalysts are especially well suited for cross‐coupling reactions with organozinc pivalates, a class of organozinc reagents with enhanced stability towards air and moisture. Furthermore, we discuss applications of cobalt‐catalysis in Negishi cross‐coupling reactions (sp 2 ‐sp 2 , sp‐sp 2 , sp‐sp 3 ) as well as electrophilic aminations using organozinc reagents.

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