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Cobalt‐Catalyzed Cross‐Couplings and Electrophilic Aminations using Organozinc Pivalates
Author(s) -
Lutter Ferdinand H.,
Graßl Simon,
Grokenberger Lucie,
Hofmayer Maximilian S.,
Chen YiHung,
Knochel Paul
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900070
Subject(s) - cobalt , electrophile , catalysis , negishi coupling , chemistry , reagent , combinatorial chemistry , palladium , transition metal , organic chemistry
Transition metal catalyzed cross‐couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt‐salts offer a useful alternative to other common metal‐catalysts (e. g. palladium‐complexes). In this review, we report that cobalt‐catalysts are especially well suited for cross‐coupling reactions with organozinc pivalates, a class of organozinc reagents with enhanced stability towards air and moisture. Furthermore, we discuss applications of cobalt‐catalysis in Negishi cross‐coupling reactions (sp 2 ‐sp 2 , sp‐sp 2 , sp‐sp 3 ) as well as electrophilic aminations using organozinc reagents.