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Titanocene‐Catalyzed Sequential Carbocarboxylation of Dienes and Alkenes with Organic Halides and Carbon Dioxide in the Presence of n BuMgCl
Author(s) -
Hang Wei,
Zou Song,
Xi Chanjuan
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201802082
Subject(s) - halide , chemistry , synthon , catalysis , regioselectivity , organic chemistry , radical , organic synthesis , carbon dioxide , magnesium , alkene , medicinal chemistry
A titanocene‐catalyzed regioselective carbocarboxylation of dienes or alkenes has been developed. This reaction proceeds efficiently to form flexible and versatile carboxylic acids in the presence of n BuMgCl by the combined use of dienes or alkenes with organic halides and CO 2 as the carbon synthon and carboxyl group, respectively. 2,3‐Disubstituted 1,3‐butadienes were used to afford acrylic acids in excellent yields with various organic halides. In the most cases, the arylalkenes afforded benzylic acids in high yields under similar conditions. The titanocene catalyst plays important roles in the generation of radicals and allyl‐ or benzyl‐magnesium halides.