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Bench‐Stable Cobalt Pre‐Catalysts for Mild Hydrosilative Reduction of Tertiary Amides to Amines and Beyond
Author(s) -
Nurseiit Alibek,
Janabel Jaysan,
Gudun Kristina A.,
Kassymbek Aishabibi,
Segizbayev Medet,
Seilkhanov Tulegen M.,
Khalimon Andrey Y.
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201801605
Subject(s) - cobalt , hydrosilylation , catalysis , chemistry , silane , amide , organic chemistry , combinatorial chemistry
The readily synthesized and bench‐stable cobalt dichloride complex (dpephos)CoCl 2 is employed as a pre‐catalyst for a diversity of silane additions to unsaturated organic molecules, including the normally challenging reduction of amides to amines. With regard to hydrosilative reduction of amides even more effective and activator free catalytic systems can be generated from the bench‐stable, commercially available Co(acac) 2 and Co(OAc) 2 with dpephos and PPh 3 ligands. These systems operate under mild conditions (<100 °C), with many examples of room temperature transformations, presenting a first example of mild cobalt‐catalyzed hydrosilylation of amides.